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Thus, finally, we consider pertinent the union of efforts between the public and private sector, together with research centers, to advance works that explore and investigate other less toxic substances or metals that can replace or minimize the impact of the heavy metals described in this work

People with gastrointestinal conditions Conditions like celiac disease, Crohn disease, or other malabsorption syndromes already impair B12 absorption

Candida albicans possess a highly versatile and dynamic high-affinity iron transport system important for its commensal-pathogenic lifestyle

The functional assays of CYP3A4 further validate this claim: iHLOs exhibited a concentration-dependent inhibition profile following ketoconazole treatment (IC 50 : 0.83 M), comparable to HepaRG cells but distinct from PHHs

4.2 Wnt/-Catenin signaling pathway and HCC progression 4.2.1 Cancer stem cells Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), possess self-renewal and differentiation abilities comparable to normal stem cells, and are pivotal in the initiation, recurrence, and metastasis of tumors (95)

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